Association between insulin resistance with UCP2 -866G/A, UCP2 45BP INS/DEL, UCP3 -55C/T, GHSR1A RS2922126, GHSR1A RS509035 and PRO12ALA PPARΓ2 gene polymorphisms in obese female adolescents in Yogyakarta, Indonesia
نویسندگان
چکیده
Methods Screening for obesity using CDC 2000 criteria was done in 2121 female adolescents aged 13-14 years old in Yogyakarta. BMI > 95 percentile was considered as obese. Among the obese subjects, 78 agreed to be enrolled for this study. HOMA-IR > 3.16 was used to determine the insulin resistance status. DNA was isolated from peripheral blood and UCP2 -866 G/A, UCP3 -55C/T, GHSR1a rs2922126, GHSR1a rs509035 and Pro12Ala PPARg2 genotypes were analyzed by PCRRFLP. UCP2 45bp ins/del genotype was analyzed by PCR.
منابع مشابه
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عنوان ژورنال:
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013